Nonerosive reflux disease (NERD), a subcategory of GERD, is a heterogeneous disorder characterized by troublesome reflux-related symptoms in the absence of endoscopic evidence of esophageal mucosal erosions or breaks. Approximately 50-85% of patients with reflux-related symptoms that are accompanied by negative endoscopic findings are diagnosed with NERD. It is estimated that more than two-thirds of GERD patients have NERD.
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